AN ASSESSMENT OF THE FUNGICIDAL ACTIVITY OF ANTIMICROBIAL AGENTS USED FOR HARD-SURFACE AND SKIN DISINFECTION
- 1 June 1986
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 11 (3), 199-205
- https://doi.org/10.1111/j.1365-2710.1986.tb00845.x
Abstract
Trichophyton mentagrophytes and Aspergillus niger conidia and Candida albicans blastospores were employed to assess the fungicidal activity of a range of antimicrobial agents used for hard-surface and skin disinfection in hospitals in the U.K. The antimicrobials were tested at in-use concentrations. The time taken to give > 99.99% kill was determined by estimating the number of survivors (cfu/ml) at a variety of time intervals after exposure of washed suspensions of spores to the disinfectants. At equivalent times the recovery in the broth was investigated. An alcoholic solution of chlorhexidine gluconate (0.02%) (Hibitane), iodine in Industrial Methylated Spirit (IMS) and a phenolic (0.36% phenols, Stericol) produced a 99.99% kill of all species within 2 min, alcoholic and aqueous solutions (10%) of povidone-iodine (Betadine) and hypochlorite (0.2%) required 10 min to give a 99.99% kill of all species tested. The preparation which contained cetrimide (Cetavlon), aqueous solutions of chlorhexidine gluconate (Hibitane) and combinations of these (Savloclens and Savlodil) were only slowly fungicidal, particularly against T. mentagropytes spores, which was the most resistant of the three fungal species to disinfection.This publication has 7 references indexed in Scilit:
- Outbreak of systemic Candida albicans in intensive care unit caused by cross infection.BMJ, 1985
- An evaluation of the fungicidal activity of disinfectants commonly used in clinical practiceJournal of the American Podiatric Medical Association, 1982
- Aspergillosis and other systemic mycoses. The growing problemJAMA, 1979
- Microbiological Applications of the Inactivation of Antibiotics and Other Antimicrobial AgentsJournal of Applied Bacteriology, 1979
- Survival and resistance of Trichophyton mentagrophytes arthrosporesApplied and Environmental Microbiology, 1978
- The estimation of the bactericidal power of the bloodEpidemiology and Infection, 1938