Thyroid Hormone Action: In vitro Demonstration of Putative Receptors in Isolated Nuclei and Soluble Nuclear Extracts
- 14 June 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 184 (4142), 1188-1191
- https://doi.org/10.1126/science.184.4142.1188
Abstract
Saturable binding activities for triiodothyronine were demonstrated in vitro with isolated nuclei and soluble nuclear extracts of rat liver, kidney, and cultured GH1 cells. The binding activity can be extracted from nuclei in soluble form with no significant change in hormone affinity and has properties of a nonhistone protein.Keywords
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