THYMUS-DEPENDENT LYMPHOCYTES OF DENGUE VIRUS-INFECTED MICE SPLEENS MEDIATE SUPPRESSION THROUGH PROSTAGLANDIN

Abstract

Apparently transfer of spleen cells obtained from dengue type 2 virus (DV)-primed mice suppressed DV antigen-specific antibody secretion as detected by Jerne plaque-forming cell technique. The suppression was produced by non-glass-adherent cells, macrophage-depleted (by carbonyl Fe) cells and by splenic T lymphocytes, but not by the glass-adherent cells and B lymphocytes. The activity of these cells is dependent upon prostaglandin [PG] production as shown by abrogation of their suppressor activity by pre-treatment of cells by indomethacin or aspirin, which are known to block Pg synthesis.