Studies of experimental cervical spinal cord transection

Abstract

Two distinct and sequential patterns of hemodynamic alteration were observed after acute cervical spinal cord transection in anesthetized dogs. Interruption of the cord initially caused a 45% increase in mean arterial pressure (P < 0.01), a 34% increase in systemic vascular resistance (P < 0.05) and a 92% increase in left ventricular dp/dt (maximum rate of fall in left ventricle pressure) (P < 0.01), reflecting a generalized sympathetic response to trauma. Concomitant bradycardia and escape arrhythmias suggested relative parasympathetic hyperactivity. Resolution of the brief pressor response was followed by a 2nd, more prolonged period characterized by a fall in arterial pressure to 71% of control levels (P < 0.05), a 16% decrease in systemic vascular resistance and a 58.5% decrease in left ventricular dp/dt (P < 0.01). These latter hemodynamic changes were consistant with sympathetic denervation and failure of regulatory mechanisms mediated by both .alpha.- and .beta.-adrenergic peripheral vascular and myocardial receptors.