Alteration in Mammalian Nerve Metabolism by Soluble and Gaseous Anesthetics
- 30 November 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (3), 573-578
- https://doi.org/10.1152/ajplegacy.1956.187.3.573
Abstract
A variety of anesthetics (chloretone, phenobarbital, cyclopropane, nitrous oxide and xenon) in sufficient quantities will reversibly abolish excitation and conduction in isolated rat sciatic nerve. Under these conditions, in parallel experiments certain aspects of the resting respiration (O2 consumption) and carbohydrate metabolism (pyruvate utilization) of mammalian nerve have been measured. The rate of O2 uptake in resting nerve may be significantly diminished by at least four of these agents under conditions which do not alter excitation and conduction. Blockade concentrations or partial pressures were found to inhibit the resting respiration of nerve from 50–85%. Pyruvate utilization by nerve was not always diminished by anesthetics in a manner parallel to the alteration in the resting respiration. An equivalent depression of electrical activity produced in nerve by each substance was by no means accompanied by the same pattern of alteration in nerve metabolism. These results are similar to those of Larrabee and Edwards (1955) obtained with rat autonomic ganglia although quite different anesthetic agents were employed.Keywords
This publication has 11 references indexed in Scilit:
- SELECTIVE ACTION OF ANESTHETICS ON SYNAPSES AND AXONS IN MAMMALIAN SYMPATHETIC GANGLIAJournal of Neurophysiology, 1952
- THE ENZYMATIC MECHANISM OF BARBITURATE ACTION1950
- ACTION OF METHYL FLUOROACETATE ON RESPIRATION AND POTENTIAL OF NERVEAmerican Journal of Physiology-Legacy Content, 1949
- THE EFFECTS OF ASPHYXIATION AND NARCOSIS ON PERIPHERAL NERVE POLARIZATION AND CONDUCTIONAmerican Journal of Physiology-Legacy Content, 1947
- The effect of metabolic inhibitors on the resting potential of frog nerveJournal of Cellular and Comparative Physiology, 1942
- The catatorulin test for vitamin B1Biochemical Journal, 1938
- The effects of narcotics on tissue oxidationsBiochemical Journal, 1937
- THE MECHANISM OF THE ARSENITE ACTION ON MEDULLATED NERVEAmerican Journal of Physiology-Legacy Content, 1935
- NERVE METABOLISMPhysiological Reviews, 1932
- THE GAS EXCHANGE OF NERVE DURING STIMULATIONAmerican Journal of Physiology-Legacy Content, 1927