The cutaneous manifestations of sulfathiazole intoxication have been recently described by Volini, Levitt and O'Neil.1They reported an incidence of 3.9 per cent in a group of 180 cases. Urticarial, erythematous, macular, papular, nodular and purpuric eruptions were encountered; the nodular lesion probably represented the advanced stage of a toxic rash and has been the most serious lesion, having been associated with a fatal outcome in a high percentage of cases. Among 400 pneumonia patients treated with sulfathiazole reported from the Philadelphia General Hospital2the incidence of cutaneous rashes was 3.7 per cent. There were no cases of acute exfoliative dermatitis observed and to our knowledge there are no reports in the literature of this condition. It seems worth while that the following case be reported. REPORT OF CASE History.— R. A., a Negro aged 38, admitted March 17, 1941 to the Philadelphia General Hospital in the