THE ACTION OF INSULIN ON THE MOTILITY OF THE EMPTY STOMACH

Abstract

In 5 normal dogs with gastric fistulae the intravenous injection of insulin produced a primary depression of tonus and contractions of the stomach followed by an increase in tonus and gastric activity which passed into a regular type III activity, or incomplete gastric tetany. This is a true insulin effect because the same type of response is obtained ton injection of crystalline preparations. The insulin response in normal dogs is identical with that reported for pan-createctomized dogs. The increased sympathetic activity and increased adrenalin output after insulin (Cannon, McIver and Bliss) have been correlated with the increased gastric activity (Bulatao and Carlson) .