The Plasmatic 11-Hydroxy-Corticosteroid Response in the Human to a Synthetic Octadecapeptide Corticotropin (C-41795-Ba)

Abstract

The adrenal response as measured by the plasmatic changes in 11-hydroxy-corticosteroid (11-OHCS) concentration following the administration of a synthetic octadecapeptide (C-41795-Ba) was compared in 17 normal young males with that obtained with the commercially available tetracosactrin. C-41795-Ba polypeptide shows a higher potency than tetracosactrin. Its effects are longer lasting when administered intravenously which indicates a significant local inactivation of the polypeptide. 1 Part of the results were presented at the 14 Meeting of the Spanish Society for Physiological Sciences, 1973.