Purines, pyrimidines, and imidazoles. Part XXXIII. Synthesis of 5-methylsulphonyluridine and its 5′-mono- and pyro-phosphates

Abstract

5-Methylthiouridine tri-O-benzoate and 5-methylsulphonyluridine have been prepared. The latter gave a crystalline triacetate and an isopropylidene derivative, which when phosphorylated by different methods gave via the intermediate 2′,3′-isopropylidene-5-methylsulphonyluridine 5′-phosphate, 5-methylsulphonyluridine 5′-phosphate. The monophosphate was converted into the corresponding pyrophosphate in various ways. The reactions and preparations of some of the intermediates are discussed.