Characterisation of a synergohymenotropic toxin produced by Staphylococcus intermedius
- 4 December 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 376 (3), 135-140
- https://doi.org/10.1016/0014-5793(95)01260-9
Abstract
Staphylococcal synergohymenotropic (SHT) toxins damage membranes of host defence cells and erythrocytes by the synergy of two secreted and non‐associated proteins: class S and class F components. Whereas Panton‐Valentine leucocidin (PVL), γ‐hemolysin and Luk‐M from Staphylococcus aureus are members of this toxin family, a new bi‐component toxin (LukS‐I + LukF‐I) from Staphylococcus intermedius, a pathogen for small animals, was characterised and sequenced. It is encoded as a luk‐I operon by two cotranscribed genes, like PVL. LukS‐I + LukF‐I shares a strong leukotoxicity of various PMNs, but only slight haemolytic properties on rabbit erythrocytes. When intradermally injected into rabbit skin, a 100 ng dose caused acute inflammatory reaction leading to tissue necrosis. The new SHT seemed to be largely distributed among various Staphylococcus intermedius strains.This publication has 37 references indexed in Scilit:
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