Testicular Hilar Nodules in Adrenogenital Syndrome

Abstract

A controversy over the nature of occasionally noted nodules in the testicular hilus in male infants with the adrenogenital syndrome has arisen from several reports.^1,2The difference of opinion is whether they represent Leydig cells¹or adrenal cells.²The use of cortical steroids since 1950 in the treatment of this syndrome has yielded much information on the metabolic disorders involved 3 but has not revealed the nature of the testicular hilar nodules. A case showing a differential tissue response to injury between the adrenals and the testicular hilar nodules is reported. A survey of the previously reported cases is presented. Report of Case A three-year-old white male child was admitted to the University of Florida Teaching Hospital for the first and only time on Sept 22, 1959, about six months prior to death. A large penis had been noted at birth. A similar finding had been noted in