Expression of c‐fos, c‐jun, jun‐B, metallothionein and metalloproteinase genes in human chondrocyte
- 20 July 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 306 (2-3), 169-172
- https://doi.org/10.1016/0014-5793(92)80992-p
Abstract
Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP-1) genes; c-fos, c-jun and jun-B. Among the late AP-1 responsive genes, total matallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT-IIA mRNA levels were elevated only in OA individuals. Despite the common AP-1 sequences present in their promoter regions, the three late genes were differentially expressed.Keywords
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