The Teratogenic Effects of E‐64 on Rat Embryogenesis
- 9 October 1990
- journal article
- Published by Wiley in Pediatrics International
- Vol. 32 (5), 495-501
- https://doi.org/10.1111/j.1442-200x.1990.tb00869.x
Abstract
To examine the effects of E-64 (a thiol protease inhibitor) on the development of rat embryos, pregnant Wistar rats were injected with 10-30 mg/kg of E-64 intra-peritoneally on days 9 and 10 of gestation. On day 21, the rats were killed and the fetuses were examined for malformations. When 30 mg/kg of E-64 was administered, the incidence of resorptions and malformations was 25.7% and 60.4%, respectively. The most common malformations were hydrocephaly, exencephaly, anophthalmia, microphthalmia, hydronephrosis and renal hypoplasia. These results suggest that thiol protease inhibitor is teratogenic during early rat embryogenesis.Keywords
This publication has 6 references indexed in Scilit:
- Synergistic effect of subteratogenic doses of antisera on the development in the ratTeratology, 1984
- The Production of Cardiovascular Malformations with Combined Use of Antisera to Kidney and Fetal HeartCongenital Anomalies, 1984
- Inhibitions by E-64 Derivatives of Rat Liver Cathepsin B and Cathepsin L In Vitro and In Vivo 1The Journal of Biochemistry, 1980
- Isolation and characterization of E-64, a new thiol protease inhibitor.Agricultural and Biological Chemistry, 1978
- A rapid method for detecting malformations in rat fetusesJournal of Morphology, 1969
- Production of Congenital Malformations Using Tissue Antisera III. Placental Antiserum.Experimental Biology and Medicine, 1967