Effect of Ischemia and Reoxygenation on Glycolytic Reactions and Adenosinetriphosphate in Heart Muscle
- 1 September 1960
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 8 (5), 965-971
- https://doi.org/10.1161/01.res.8.5.965
Abstract
During a 15-minute period of myocardial ischemia, glycogen concentration fell. This decrease was roughly accounted for by increases in hexosemonophosphate and lactic acid. Fructose 1,6-diphosphate, dihydroxyace-tone-phosphate and pyruvate did not accumulate. The myocardial concentration of adenosinetriphosphate declined. Reperfusion of the ischemie heart with oxygenated blood was accompanied by inconstant changes in myocardial glycogen and by rapid lowering of hexosemonophosphate. The hexosemonophosphate decrease occurred even when the ischemie myocardium was perfused with a deoxygenated buffered salt solution and is attributed in part at least to lactic acid washout. Adeno-sinetriphosphate rose steadily when the heart was perfused with oxygenated blood containing 15 mmoles KCl to prevent cardiac activity. When KCl was not added, fibrillation and irregular contractions occurred within 1 to 2 minutes. In these instances, the rise in adenosinetriphosphate was irregular and inconstant.Keywords
This publication has 8 references indexed in Scilit:
- Metabolic changes in heart muscle during anoxiaAmerican Journal of Physiology-Legacy Content, 1959
- STUDIES OF TISSUE PERMEABILITY .2. THE DISTRIBUTION OF PENTOSES BETWEEN PLASMA AND MUSCLE1957
- Content of Inorganic and High Energy Phosphates, Potassium, Sodium, Lactate and Glycogen in Different Areas of the Dog HeartAmerican Journal of Physiology-Legacy Content, 1956
- THE DETERMINATION OF GLYCOGEN IN LIVER AND MUSCLE BY USE OF ANTHRONE REAGENTJournal of Biological Chemistry, 1956
- Levels of enzymes of the direct oxidative pathway of carbohydrate metabolism in mammalian tissues and tumoursBiochemical Journal, 1954
- Diphosphofructose-Aldolase, Phosphoglyceraldehyd-Dehydrogenase, Milchsäure-Dehydrogenase, Glycerophosphat-Dehydrogenase und Pyruvat-Kinase aus Kaninchenmuskulatur in einem ArbeitsgangZeitschrift für Naturforschung B, 1953
- Nucleotide Metabolism in Cardiac ActivityCirculation Research, 1953
- Role du magnésium et du potassium dans la réaction fructokinasiqueBiochimica et Biophysica Acta, 1952