HLA-DQ heterogeneity among HLA-DRw11(5) haplotypes
- 11 December 2008
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 28 (5), 278-287
- https://doi.org/10.1111/j.1399-0039.1986.tb00497.x
Abstract
Class II molecular variation among a panel of ten HLA-DRw11(5) homozygous cell lines (HCL) was investigated by analysis of restriction fragment length polymorphisms in genomic DNA. Hybridization of Bgl II, HindIII, and Taq I digested cellular DNA with DQ .alpha. and DQ .beta. cDNA probes identified a clustering of characteristic polymorphisms. Considerable diversity was observed between the hLA-DRw-11(5), DQw3 positive haplotypes studied, as well as compared to a DRw11(5), DQw1 positive haplotype. In contrast to the observed DQ genomic variability, hybridization with a DR .beta. probe revealed relatively limited diversity. The molecular heterogeneity seen by genomic restriction fragment analysis illustrates the presence of genomic polymorphisms, particularly within HLA-DQ-related genes among a family of DRw11(5)-related haplotypes.This publication has 32 references indexed in Scilit:
- Allelic polymorphism and transassociation of molecules encoded by the HLA-DQ subregion.Proceedings of the National Academy of Sciences, 1985
- Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.Proceedings of the National Academy of Sciences, 1984
- Isotypic and allotypic variation of human class II histocompatibility antigen α-chain genesNature, 1984
- HLA-D Region Monoclonal AntibodiesPublished by Springer Nature ,1984
- Antigen Report: HLA-DR5 and Its Subtypes HLA-DRw11 and HLA-DRw12Published by Springer Nature ,1984
- Biochemistry of Class II Antigens: Workshop ReportPublished by Springer Nature ,1984
- The HLA System, 1984Published by Springer Nature ,1984
- Role of MHC Gene Products in Immune RegulationScience, 1981
- B-Lymphoid cell lines derived fromHLA-D homozygous donorsImmunogenetics, 1979
- The Serological Recognition of the Human MLC Determinants using a Modified Cytotoxicity TechniqueTissue Antigens, 1975