Lymphocyte inclusions in the juvenile type of generalized ceroid-lipofuscinosis
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 36 (4), 327-338
- https://doi.org/10.1007/bf00699638
Abstract
Peripheral blood lymphocytes exhibiting cytoplasmic vacuoles from eight patients with the juvenile type of generalized ceroid-lipofuscinosis were investigated by electron microscopy. Osmiophilic inclusions could be demonstrated in the vacuoles and occasionally in the cytoplasm proper, revealing a fingerprint-like ultrastructural pattern or a less defined dense granular material, sometimes with an osmiophobic component adjoined. The inclusions are compared with those demonstrated in seven of the cases by earlier investigations of rectal biopsies in a variety of cell types, mainly in nerve cells. Discrimination is attempted between the lymphocyte inclusions and “parallel tubular arrays” regarded as representing a regular lymphocyte constituent.Keywords
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