Exogenous Prostaglandin F2α Promotes Uterine Involution in the Cow

Abstract
Three newly delivered dairy cows were given prostaglandin F during the immediate postpartum period. PGF was administered from day 3–13 post partum in doses of 25 mg twice daily. Endogenous release of PGF and progesterone was studied in blood plasma during the experimental period. Rectal examination of the uterus was performed every second day in order to establish the end of uterine involution. Uterine involution in the three cows was completed days 16, 23 and 20, respectively. These figures are to be compared with earlier investigations of uterine involution times, which show about 27 days. It was concluded that PGF had a positive effect on the uterine muscular tone.