Sirenomelia and Monomelia with Renal Agenesis and Amnion Nodosum

Abstract

Two cases of sirenomelia and two of monomelia have been described in view of additional features not mentioned in previous reports. The Potter facies, large spade-like hands and pulmonary hypoplasia were present in all four cases. Examination of the placentae in 3 cases revealed the lesion of amnion nodosum a finding indicative of oligohydramnios, which was in fact noted clinically in 2 instances. We conclude that severe urinary tract dysplasia, such as renal agenesis or complete urethral atresia, and its associated fetal and placental changes are a constant finding in sirenomelia and monomelia.