Some Properties of Yoshida Sarcoma Cells Resistant to Methyl-bis-( -chlorethyl)-amine N-oxide.
- 1 January 1955
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 88 (1), 147-149
- https://doi.org/10.3181/00379727-88-21519
Abstract
A variant of the Yoshida sarcoma which became resistant to methylbis-(beta-chlorethyl)-amine N-oxide (MBAO) upon passage through animals treated with the agent, was demonstrated to be resistant to 3 other alkylating agents, methylbis-(beta-chlorethyl)-amine, tris-(beta-chlorethyl)-amine and tris-ethylenimino-s-triazine. It proved sensitive to another unrelated antitumor agent, colchicine. Resistance to MBAO has remained unchanged following 24 consecutive serial transfers in rats free of the agent.Keywords
This publication has 3 references indexed in Scilit:
- Studies on an Ascites (Reticuloendothelial Cell?) Sarcoma of the Rat234JNCI Journal of the National Cancer Institute, 1952
- A Comparison of the Effects of 4-Amino-N10-Methyl-Pteroylglutamic Acid and 2,6-Diaminopurine upon Sensitive and Resistant Sublines of a Strain of Mouse LeukemiaBlood, 1951
- Development of Resistance to Folic Acid Antagonists in a Transplantable Lymphoid LeukemiaExperimental Biology and Medicine, 1950