Lesions of the Pancreatic Islets Produced in Cats by Administration of Glucose
- 14 February 1947
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 105 (2720), 183
- https://doi.org/10.1126/science.105.2720.183
Abstract
Hydropic degeneration of the islands of Langerhans and permanent severe diabetes mellitus have followed the prolonged injection of intraperitoneal glucose-saline solution in normal as well as in partially depancreatized cats. Positive results were associated with prolonged hyperglycemia. These findings add further evidence in support of the hypothesis that a sustained elevation of blood glucose may, under certain conditions, lead to the production of damage to the islands of Langerhans in this species. Besides hyperglycemia, other disturbances which might be responsible wholly or in part for the island lesions are under study.Keywords
This publication has 3 references indexed in Scilit:
- PITUITARY-DIABETES IN THE CAT: RECOVERY FOLLOWING PHLORHIZIN TREATMENT1Endocrinology, 1943
- PITUITARY-DIABETES IN THE CAT; RECOVERY FOLLOWING INSULIN OR DIETARY TREATMENTEndocrinology, 1942
- The Prevention of DiabetesNew England Journal of Medicine, 1940