Adhesion Molecules Involved in the Microvascular Inflammatory Response
- 1 November 1992
- journal article
- review article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 146 (5_pt_2), S45-S50
- https://doi.org/10.1164/ajrccm/146.5_pt_2.s45
Abstract
Accumulation of leukocytes in tissues is essential for effective host defense. To fulfill this role the cell must interact with and penetrate the vessel wall and migrate in the tissue. It is now clear that cell adhesion molecules play a crucial role in orchestrating these processes. A number of families of such adhesion molecules that mediate the interaction of circulating leukocytes and vascular endothelial cells have been identified. These include the leukocyte integrins, the selectins, members of the immunoglobulin family, and certain carbohydrates. Studies in vitro have elucidated which of these adhesion molecules are important in the interaction of different leukocyte classes with the endothelium under both basal and stimulated conditions. With the aid of monoclonal antibodies, the role that these molecules play in the interaction of inflammatory cells in the microvasculature in vivo is being assessed. Studies to date have demonstrated the key role of cell adhesion molecules in inflammation.Keywords
This publication has 23 references indexed in Scilit:
- Endothelial leukocyte adhesion molecule-1 mediates antigen-induced acute airway inflammation and late-phase airway obstruction in monkeys.JCI Insight, 1991
- Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrinsCell, 1991
- Carbohydrate ligands of the LEC cell adhesion moleculesCell, 1990
- Adhesion receptors of the immune systemNature, 1990
- Identification of surface proteins mediating adherence of CD11/CD18-deficient lymphoblastoid cells to cultured human endothelium.JCI Insight, 1990
- Rapid neutrophil adhesion to activated endothelium mediated by GMP-140Nature, 1990
- Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthmaScience, 1990
- Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytesCell, 1989
- Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium.JCI Insight, 1988
- Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay.The Journal of Experimental Medicine, 1983