Protection Afforded by Aqueous-Alcohol Solutions of Cortisone Against Dextran.

Abstract

Intramusc. injns. of aqueous-alcohol solns. of cortisone are much superior to microcrystalline suspensions commercially available in affording protection to the 24 -hr. adrenalectomized rat infused with dextran. The amt. of soluble steroid required to give adequate protection is 30 times less than that found necessary when the suspension is used and the requisite time for prophylactic fore-treatment is reduced from 5 days to 6 hrs. The procedure employed in the expts. can be utilized as the basis for a simple screening test for compounds with cortisone-like activity.