Tietze's syndrome, a painful, benign, nonsuppurative swelling of the costochondral or the sternoclavicular junction, was originally described over 30 years ago in Germany.1It is timely to review it now when both physicians and laymen, increasingly cognizant of coronary artery disease and malignant disease, view the development of chest pain with alarm. In American medical reports, Tietze's syndrome has not been discussed except for the single report of Motulsky and Rohn2in 1953 that described two cases associated with Hodgkin's disease. The frequency of Tietze's syndrome justifies its uniform inclusion in the differential diagnosis of chest pain. Over 100 patients with chest pain occasioned by this syndrome have been described by foreign authors, who suggest that it is commoner than is recognized. During the past three years I have observed four patients with Tietze's syndrome without concurrent disease. Two of these patients were part of a series of