Preliminary Studies of the Distribution and Fate of 82Br-labelled 2-brom-D-Lysergic Acid Diethylamide (BOL) in the Human Body

Abstract

In a study of Br82-BOL in humans, the time course of distribution was followed in liver, spleen, intestines, lung, head and blood. Excretion was studied by whole body counting and measurement of urine and feces. The results showed an initial accumulation in the liver and a later concentration of activity in the lower abdomen, but no marked accumulation of tracer in other organs. In the blood the activity increased steadily for nine hours and then remained constant for 48 hours; formed blood elements contained half as much activity as plasma. Over a period of 6 days, 50% of the tracer was excreted, 91% of it via urine. The results described agree only in part with those found with LSD in animals by other authors.