Effect of Liver Damage on Experimental Renal Hypertension in the Rat

Abstract

Renal hypertension was produced in 26 test rats and fell to normal levels when they received CCl₄. Our data indicate that this is due to liver damage and not to general inanition. These changes are reversible, since cessation of CCl₄ injections led to blood pressure rise. Morphologically, only a moderate degree of fatty metamorphosis is necessary to cause the blood pressure to fall from hypertensive levels to normotension. The biochemical change involved variable changes in albumin and globulin.