Spectinomycin modification. III. Spectinomycin analogs with C-3'-branched chain sugars.

Abstract

A variety of C-3''-branched chain analogs of spectinomycin was synthesized via the intermediacy of spectinomycin derived diazoketones. In vitro antibacterial assay of these compounds underscored the importance of H bonding functional groups in this region of the molecule. The most potent of these analogs had activity greater than or equal to the parent.