Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac Dysfunction
- 24 May 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 111 (20), 2596-2604
- https://doi.org/10.1161/circulationaha.104.490979
Abstract
Background— Although most of the deleterious effects of sepsis-induced apoptosis have been attributed to increased lymphocyte cell death, caspase activation may directly alter cell function of diff...Keywords
This publication has 25 references indexed in Scilit:
- The Pathophysiology and Treatment of SepsisNew England Journal of Medicine, 2003
- Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosisCell Death & Differentiation, 2002
- Blocking Caspase-Activated Apoptosis Improves Contractility in Failing MyocardiumHuman Gene Therapy, 2001
- Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic ratsThe FASEB Journal, 2000
- Caspase inhibitorsCell Death & Differentiation, 1999
- Inhibition of Human Caspases by Peptide-based and Macromolecular InhibitorsJournal of Biological Chemistry, 1998
- Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.The Journal of Experimental Medicine, 1996
- A Synthetic Inhibitor of Interleukin-lβ Converting Enzyme Prevents Endotoxin-Induced Interleukin-lβ ProductionIn VitroandIn VivoJournal of Interferon & Cytokine Research, 1995
- The Cardiovascular Response of Normal Humans to the Administration of EndotoxinNew England Journal of Medicine, 1989
- A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.Journal of Clinical Investigation, 1985