Formation of 3-hydroxybutan-2-one and butane-2:3-diol by pig-heart preparations and its relationship to oxidation of pyruvate
- 1 November 1957
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 67 (3), 456-463
- https://doi.org/10.1042/bj0670456
Abstract
Pyruvate and mixtures of pyruvate and acetaldehyde will both act as substrates for formation of 3-hydroxybutan-2-one by the use of a pig-heart preparation capable of formation of citrate. The formation of a-acetyl-lactic acid by the system has been indicated in the presence of a large excess of pyruvic acid relative to acetaldehyde. Manganese (Mn++) ions stimulate the production of 3-hydroxybutan-4-one from acetaldehyde. Acetaldehyde and thioctic acid compete for the products of decarboxylation of pyruvic acid by this system.Keywords
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