STRUCTURAL-CHANGES IN FREEZE-FRACTURED SARCOLEMMA OF ISCHEMIC MYOCARDIUM
- 1 January 1977
- journal article
- research article
- Vol. 88 (3), 583-594
Abstract
Ultrastructural alterations in the sarcolemma of ischemic myocardium were studied with the freeze-fracture technique. In normal dog myocardial sarcolemma, the P fracture face contained many intramembranous particles which were randomly distributed, while the E fracture face had few intramembranous particles; no structural abnormalities were seen within the lipid bilayer on either face. Myocardium ischemic for 45 min displayed no, or only slight, aggregation of intramembranous particles, but upon reperfusion for 5-20 min, the particles became significantly aggregated in the P face. Scattered nicks within the lipid bilayer were observed on both fracture faces. Intramembranous particles were similarly aggregated in myocardium ischemic for 2 h. The number of nicks were greatly increased on the P and E fracture faces. These structural alterations which were undetected in thin sections, are likely to be associated with altered function in the sarcolemma of ischemic myocardium.This publication has 14 references indexed in Scilit:
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