Abnormalities in Parathyroid Hormone Secretion and 1,25-Dihydroxyvitamin D3Formation in Women with Osteoporosis

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Abstract
To the Editor: Silverberg et al. (Feb. 2 issue) 1 provide important information on abnormalities of parathyroid hormone (PTH) secretion and 1,25-dihydroxyvitamin D3 (1,25(OH)2D) formation in osteoporosis. Changes in the secretion of PTH were attributed to natural aging and the disease process of osteoporosis. However, the results could be explained on the basis of chronic or severe magnesium deficiencies. Magnesium influences PTH secretion2 3 4 and both renal and skeletal sensitivity to PTH.4 , 5 In rats, magnesium deficiency has resulted in osteoporosis and the cessation of bone growth.6 , 7 In the progression from a normal magnesium nutritional status to a severe deficiency, . . .