Mapping in the region of Danforth's short tail and the localization of tail length modifiers.
Open Access
- 1 February 1997
- journal article
- Published by Cold Spring Harbor Laboratory in Genome Research
- Vol. 7 (2), 108-117
- https://doi.org/10.1101/gr.7.2.108
Abstract
We have used an interspecific backcross to generate a detailed genetic map around the mouse tail and kidney developmental mutation Danforth's short tail (Sd). The map includes 14 simple sequence repeat (SSR) markers and four genes in a 5-cM region encompassing Sd. In addition we have used a DNA pooling approach to carry out a genome scan to localize quantitative trait loci (QTL) that modify the tail length of Sd progeny of the backcross. This has allowed us to identify a major QTL on chromosome 10 in the region of nodal and three other putative tail length QTL on chromosomes 1, 9, and 18.Keywords
This publication has 13 references indexed in Scilit:
- Detection of Obesity QTLs on Mouse Chromosomes 1 and 7 by Selective DNA PoolingGenomics, 1996
- Transformation of axial skeleton due to overexpression of bmi-1 in transgenic miceNature, 1995
- PCR-Amplification of Simple Sequence Repeat Variants from Pooled DNA Samples for Rapidly Mapping New Mutations of the MouseGenomics, 1994
- Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.Genes & Development, 1994
- Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somiteMechanisms of Development, 1993
- Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulationNature, 1993
- A simple regression method for mapping quantitative trait loci in line crosses using flanking markersHeredity, 1992
- A single gene isolated from a modifier complex in the mouseGenetica, 1972
- Development in organ tissue culture of kidney rudiments from mutant mouse embryosDevelopmental Biology, 1963
- Genetioal studies on the skeleton of the mouseJournal of Genetics, 1953