I wish to express to the officers and fellows of the College of Physicians of Philadelphia my appreciation of the honor they have conferred on me by extending an invitation to deliver the second de Schweinitz lecture. I have chosen to present a second review of the published records of severe cases of uveitis with associated alopecia, poliosis, vitiligo and deafness. In 1931 I reported 2 cases of uveitis with associated alopecia, poliosis, vitiligo and deafness and reviewed the records of 17 other cases found in the literature, basing my conclusions on the total of 19 cases.1 Since that time 10 additional cases have been reported. Five of these were reported from Cuba, 2 by Yanes and Ferrer2 and 3 by Avalos,3 1 was reported from China, by Luo,4 and 1 from South America, by Weskamp,5 and 3 were reported from the United States, 2