Teratogenic effects of combined administration of ethylenethiourea and nitrite in mice
- 1 February 1980
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 21 (1), 71-78
- https://doi.org/10.1002/tera.1420210109
Abstract
Teratogenic potential of ethylenethiourea (ETU) was investigated in SLC‐ICR mice after its reaction with sodium nitrite. ETU was given orally in dose of 400 mg/kg on various days of pregnancy in combination with 200 mg/kg NaNO2 at varied intervals. When NaNO2 was given to females immediately after their treatment with ETU on day 6 or 8 of pregnancy, fetal survival was significantly decreased. Various types of malformations were observed in the living fetuses from mothers treated on day 6, 8, or 10 of pregnancy, but not on day 12. The teratogenicity disappeared when NaNO2 was given 2 h after the treatment with ETU.This publication has 15 references indexed in Scilit:
- Induction of dominant-lethal mutations after administration of ethylenethiourea in combination with nitrite or of N-nitroso-ethylenethiourea in miceMutation Research, 1978
- Pattern of anomalies following single oral doses of ethylenethiourea to pregnant ratsTeratology, 1975
- Relative significance of dietary sources of nitrate and nitriteJournal of Agricultural and Food Chemistry, 1975
- In vivo mutagenic interaction of nitrite and ethylenethioureaCellular and Molecular Life Sciences, 1975
- Ethylenethiourea (ETU), a carcinogenic and mutagenic metabolite of ethylenebis-dithiocarbamateMutation Research, 1974
- Teratologic effects of ethylnitrosourea on brain development in ratsTeratology, 1974
- Ethylenethiourea: Teratogenicity study in rats and rabbitsTeratology, 1973
- A rapid method for detecting malformations in rat fetusesJournal of Morphology, 1969
- Developmental anomalies of the lungsThe American Journal of Surgery, 1955
- Equivalent ages in mouse and human embryosThe Anatomical Record, 1954