THE CLINICAL EPIDEMIOLOGY OF ASIAN INFLUENZA

Abstract

Asian influenza is not a new experience as judged by clinical, epidemiologic, immunologic, or serologic criteria. Immunity from Asian influenza, as with other strains, seems to relate principally to composite antibody built up through multiple exposures to the many antigenic variants of influenza A. In persons over 65 the specific component contributed by antibody sustained from earlier experiences with Asian antigen plays a subordinate though serologically discernible role. The emergence of Asian strains has been a valuable experience through which the resurgence of antigens has been shown for the first time. It has added clear support for interpretations made from earlier observations on age distribution of antibodies and their relation to initial exposure and immunity.