A hypothesis for the pathogenesis of Crohn's disease based on an ultrastructural study
- 1 January 1975
- journal article
- Published by Springer Nature in Virchows Archiv
- Vol. 365 (4), 327-336
- https://doi.org/10.1007/bf00471180
Abstract
The epithelioid cells forming the granulomata of Crohn's disease show striking vacuolation from the coalescing of pinocytotic vesicles with double membrane-bound bodies and their subsequent fusion with lysosomal dense bodies. The fine detail of the granulomata in each individual is uniform but varies from case to case in such a way as to suggest an episodic stimulation of pinocytosis and vacuole formation.Keywords
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