Neutrophil Chemotaxis Defect in IgA Deficiency Evaluated by Migration Agarose Method

Abstract

The chemotactic and random mobility functions of 12 selectively Ig[immunoglobulin]A-deficient patients were evaluated by a method using agarose gel. A severe polymorphonuclear cellular chemotactic defect was found in 10 of 12 patients; only 5 of them showed a marked associated impairment of random locomotory function. In 1 subject , levamisole therapy resulted in a dramatic improvement of chemotactic and random mobility functions. These results are discussed with respect to the possible pathogenetic implications.