Effects of Renal Hypertension on Coronary Blood Flow, Cardiac Oxygen Consumption and Related Circulatory Dynamics of the Dog

Abstract

A comparative study is presented on the circulatory dynamics of the renal hypertensive state, the stability (repeatability) of the findings in a given subject, the effect of anemia as a complicating factor and the amount of cardiac hypertrophy present in each animal at the end of the series of observations. The results indicate that in nonanemic renal hypertensive dogs with cardiac hypertrophy the coronary blood flow and cardiac oxygen consumption are the same per unit weight of myocardial tissue as in normal dogs. However, when a mild chronic anemia is a complicating factor, the coronary blood flow and the myocardial oxygen uptake are both increased. The coronary sinus venous oxygen saturation is essentially unchanged in the nonanemic hypertensives, whereas in the anemic hypertensives it is significantly lowered.