Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease
- 20 February 1987
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 235 (4791), 877-880
- https://doi.org/10.1126/science.3810169
Abstract
Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the .beta. peptide of brain amyloid from alzheimer''s disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.This publication has 20 references indexed in Scilit:
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