Metal complexes as photochemical nitric oxide precursors: Potential applications in the treatment of tumors
- 27 August 2009
- journal article
- perspective
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- No. 48,p. 10660-10669
- https://doi.org/10.1039/b912898k
Abstract
The bioregulatory molecule NO plays key roles in cancer biology and has been implicated in both tumor growth and suppression. Furthermore, it is a γ-radiation sensitizer that may enhance selective killing of neoplastic tissues. For these reasons, there is considerable interest in developing methods for NO delivery to specific physiological targets. In this Perspective, we describe ongoing investigations focused on photochemical methodologies to deliver therapeutic doses of NO to such targets utilizing transition metal complexes that are nitric oxide precursors. The photochemical strategy has the advantages that it allows for precise control of the timing, location, and dosage for the targeted delivery of a bioactive agent.Keywords
This publication has 87 references indexed in Scilit:
- Dinitrosyliron complexes and the mechanism(s) of cellular protein nitrosothiol formation from nitric oxideProceedings of the National Academy of Sciences, 2009
- Solid tumor physiology and hypoxia-induced chemo/radio-resistance: Novel strategy for cancer therapy: Nitric oxide donor as a therapeutic enhancerNitric Oxide, 2008
- Molecular mechanisms for discrete nitric oxide levels in cancerNitric Oxide, 2008
- Regulation of apoptosis-related genes by nitric oxide in cancerNitric Oxide, 2008
- Quantum Dot Fluorescence Quenching Pathways with Cr(III) Complexes. Photosensitized NO Production from trans-Cr(cyclam)(ONO)2+Journal of the American Chemical Society, 2007
- Photoactive ruthenium nitrosyls: Effects of light and potential application as NO donorsCoordination Chemistry Reviews, 2007
- Nitrosative stress in cancer therapyFrontiers in Bioscience-Landmark, 2007
- Contribution of nitric oxide-mediated apoptosis to cancer metastasis inefficiencyFree Radical Biology & Medicine, 2003
- Autoxidation kinetics of aqueous nitric oxideFEBS Letters, 1993
- Effect of Nitric Oxide on the Radiosensitivity of BacteriaNature, 1957