The Insulin Receptor of the Turkey Erythrocyte: Similarity to Mammalian Insulin Receptors
- 1 January 1977
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 100 (1), 82-90
- https://doi.org/10.1210/endo-100-1-82
Abstract
Avian erythrocytes possess insulin receptors which have binding properties that are virtually identical to those of the well studied mammalian [rat, human] insulin receptors. The affinity for porcine insulin was identical for the turkey and mammalian receptors over the entire range of insulin concentrations, as was the affinity of each of 4 insulin analogs which differed 300-fold in biological potency. Insulin induced acceleration of dissociation, i.e., the negatively cooperative site-site interaction was indistinguishable over a 106 range of insulin concentrations. Sharp pH dependence of binding was identical for turkey and mammalian receptors. The effects of temperature on association, dissociation and steady state binding were also identical. Although birds and mammals have evolved separately for 300 million yr there has been little change in the properties of the insulin receptor over this time period. [Bovine serum albumin was used.].This publication has 3 references indexed in Scilit:
- The insulin receptor of the turkey erythrocyte characterization of the membrane-bound receptorBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- Studies of Insulin, Growth Hormone and Prolactin Binding: Tissue Distribution, Species Variation and CharacterizationEndocrinology, 1974
- Insulin Receptors in Human and Animal Placental TissueDiabetes, 1974