Sister chromatid exchanges and aging
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 46 (1), 57-63
- https://doi.org/10.1007/bf00278902
Abstract
Although baseline levels of SCE appear to be similar in metaphase cells derived from young and old human skin fibroblast cultures, as significant decline in both MMC- and AAAF-induced sister chromatid exchanges was observed in the older cell populations. Considerable variation exists in the levels of MMC-induced SCE between individual cell cultures. However, parallel examination of several cell strains from young and old donors confirmed the decrease in mutagen-induced SCE frequencies in older cell populations.This publication has 24 references indexed in Scilit:
- Aging and sister chromatid exchangeExperimental Cell Research, 1978
- Aging and sister chromatid exchange I. The effect of aging on mitomycin-C induced sister chromatid exchange frequencies in mouse and rat bone marrow cells in vivoExperimental Cell Research, 1978
- Macromolecular synthesis in human diploid fibroblastsExperimental Cell Research, 1978
- Sister chromatid exchanges—A sensitive assay of agents damaging human chromosomesMutation Research, 1975
- Computer ConferencingScience, 1975
- Age-dependent excision repair of damaged thymine from γ-irradiated DNA by isolated nuclei from human fibroblastsNature, 1975
- New Giemsa method for the differential staining of sister chromatidsNature, 1974
- Rate of DNA repair in progeric and normal human fibroblastsBiochemical and Biophysical Research Communications, 1974
- Ultraviolet-Induced Repair Replication in Aging Diploid Human Cells (WI-38)Radiation Research, 1973
- AGING AND VARIABILITYAnnals of the New York Academy of Sciences, 1966