COLO-357, A HUMAN PANCREATIC ADENOSQUAMOUS CARCINOMA - GROWTH IN ARTIFICIAL CAPILLARY CULTURE AND IN NUDE-MICE

Abstract

The human pancreatic cancer cell line "COLO 357" was xenografted s.c. in athymic Swiss mice. The xenografts grew well to form typical adenosquamous carcinomas. The cells were placed in a perfused artificial capillary system where they formed a solid tumor mass which survived for 7 wk. In this system, the cells consumed glucose and released enzymes and carcinoembryonic antigen into the extracapillary space.