The effect of the fibrinolytic inhibitor epsilonaminocaproic acid on the incidence of deep-vein thrombosis after prostatectomy
- 1 July 1972
- journal article
- clinical trial
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 59 (7), 522-524
- https://doi.org/10.1002/bjs.1800590706
Abstract
Sixty‐two patients undergoing retropubic prostatectomy were examined for evidence of deep‐vein thrombosis using the 125I‐fibrinogen technique. Patients were allocated randomly into two groups. The first grops was given the fibrinolytic inhibitor epsilonminocaproic acid (EACA) during the perioperative period, while the second group of patients acted as a control. The administration of EACA did not increase the incidence of deep‐vein thrombosis after prostatectomy. This finding is discussed together with the possible role of the fibrinolytic system i postoperative venous thrombo‐embolic disease.Keywords
This publication has 14 references indexed in Scilit:
- Diagnostic Accuracy in Venous ThrombosisBMJ, 1970
- 125I-labelled fibrinogen in the diagnosis of deep-vein thrombosis and its correlation with phlebographyBritish Journal of Surgery, 1968
- Post-prostatectomy haematuria treatment with ϵ-amino-caproic acidBritish Journal of Surgery, 1967
- Effect of diluents on blood clot lysisJournal of Clinical Pathology, 1967
- AMINOCAPROIC ACID IN THE CONTROL OF HÆMORRHAGE AFTER PROSTATECTOMY: A Controlled TrialThe Lancet, 1966
- AMINOCAPROIC ACID IN THE CONTROL OF HÆMORRHAGE AFTER PROSTATECTOMY: Safety of Aminocaproic Acid—a Controlled TrialThe Lancet, 1966
- DETECTION OF VENOUS THROMBOSIS IN THE LEGSThe Lancet, 1965
- ε-AMINOCAPROIC ACID AND OTHER INHIBITORS OF FIBRINOLYSISBritish Medical Bulletin, 1964
- Reduction of Postprostatectomy Bleeding by Epsilon-Aminocaproic AcidNew England Journal of Medicine, 1962
- The Use of Epsilon Aminocaproic Acid, a Potent Inhibitor of Fibrinolytic Activity, in the Management of Postoperative HematuriaJournal of Urology, 1961