Natural Killer Cell Stimulatory Factor (NKSF)/IL‐12 and Cytolytic Activities of PBL/NK Cells from Human Immunodeficiency Virus Type‐1 Infected Patients
- 1 July 1994
- journal article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 40 (1), 83-86
- https://doi.org/10.1111/j.1365-3083.1994.tb03437.x
Abstract
The aim of this study was to assess the effect of natural killer stimulatory factor (NKSF)/IL-12) on the cytolytic potential of natural killer (NK) cells from normal donors or HIV-1 infected individuals, at different stages of disease. The results obtained confirm the powerful ability of IL-12 to enhance PBLs' cytotoxic activity to tumour cells in normals and in those HIV-1 infected patients, with maintained cytotoxic activity. IL-12 was however poorly effective in enhancing the cytolytic potential of any donors. Similar results were obtained adding IL-2, even at doses as high as 100 IU/ml in patients with CD4 number below 200/mm3. These results should be taken into account when designing therapeutic trials of HIV-1 infection based on cytokines.Keywords
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