Cefsulodin, a cephalosporin with specific antipseudomonal activity; in vitro studies of the drug alone and in combination

Abstract

The in vitro activity of cefsulodin (CGP 7174/E, SCE 129) a new semi-synthetic cephalosporin, was examined and its interaction with other antimicrobial agents evaluated. Cefsulodin was highly active against Pseudomonas aeruginosa but relatively inactive against coliform bacilli. Combinations of cefsulodin and gentamicin were found to have additive or synergistic activity against a third of strains of Ps. aeruginosa. Combinations of cefsulodin and cefuroxime were additive rather than synergistic. The potential role of cefsulodin in the therapy of serious Gram-negative infections is discussed.