Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus
Open Access
- 15 June 2004
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 78 (12), 6688-6691
- https://doi.org/10.1128/jvi.78.12.6688-6691.2004
Abstract
Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.Keywords
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