Induction of Subacute Skeletal Fluorosis in a Case of Multiple Myeloma

Abstract

THE morbidity in multiple myeloma is chiefly related to four complications: anemia; susceptibility to infections; renal failure; and pathologic fractures and incapacitating, demoralizing bone pain.¹ The use of chemotherapy in myeloma has not been as salutary as its application to chronic lymphocytic leukemia. Ethyl carbamate, glucocorticoids, cyclophosphamide and more, recently, phenylalanine mustards have been used with varying degrees of success in the hands of different groups of investigators. Although anemia and bone pain have been ameliorated in many cases in which any one of these drugs have been given, none achieve the therapeutic effectiveness of nitrogen mustard derivatives in the . . .