EFFECTS OF HALOPERIDOL ON SCHEDULE‐INDUCED POLYDIPSIA1
- 1 January 1976
- journal article
- research article
- Published by Wiley in Journal of the Experimental Analysis of Behavior
- Vol. 25 (1), 105-112
- https://doi.org/10.1901/jeab.1976.25-105
Abstract
In dose-related amounts, the drug haloperidol attenuated schedule-induced drinking by rats prefed with 0.01-mg drug added to 0, 25, 50, 75 or all of 100 Noyes 45-mg pellets. Drug pellets also induced less drinking than did regular Noyes pellets by rats that obtained these pellets at 1-min intervals by bar pressing. Haloperidol also reduced bar pressing and, temporarily, rate of reinforcement. The results appeared not to be due to a general sedative effect of haloperidol but to its selective power to reduce angiotensin-induced drinking. Thus, schedule-induced drinking, which is abnormal in not causing satiation, is controllable by a drug that interferes with the renin-angiotensin hormone system thought to regulate normal drinking.Keywords
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