Prolactin and Contact Sensitivity
- 1 August 1981
- Vol. 36 (6), 429-431
- https://doi.org/10.1111/j.1398-9995.1981.tb01850.x
Abstract
Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate that contact sensitivity is a prolactin dependent reaction.Keywords
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