Formation of lipoxin B by the pure reticulocyte lipoxygenase
- 2 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (2), 248-252
- https://doi.org/10.1016/0014-5793(86)81026-2
Abstract
The pure reticulocyte lipoxygenase converts 5,15-DiHETE via a lipoxygenase reaction to 5,14,15-trihy-droxy-6, 8,10,12-eicosatetraenoic acid (a lipoxin B isomer) as shown by GC/MS analysis of its trimethylsilyl ether. With arachidonic acid, 15-HETE and 15-HETE methyl ester this lipoxin B isomer was also formed. The results presented here indicate that pure mammalian lipoxygenases are able to form lipoxins via sequential multiple oxygenation of arachidonic acid or its hydroxy derivatives.Keywords
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